3qjn: Difference between revisions
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==Structural flexibility of Shank PDZ domain is important for its binding to different ligands== | |||
<StructureSection load='3qjn' size='340' side='right'caption='[[3qjn]], [[Resolution|resolution]] 2.71Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3qjn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [https://pdbe.org/3qjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [https://www.ebi.ac.uk/pdbsum/3qjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref> | |||
==See Also== | |||
*[[Shank protein|Shank protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Eom SH]] | |||
[[Category: Kim HJ]] | |||
[[Category: Lee JH]] | |||
[[Category: Park H]] | |||
[[Category: Park SJ]] | |||
Latest revision as of 08:35, 20 March 2024
Structural flexibility of Shank PDZ domain is important for its binding to different ligands
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