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| [[Image:2qdz.jpg|left|200px]]<br /><applet load="2qdz" size="350" color="white" frame="true" align="right" spinBox="true" | | #REDIRECT [[4qky]] This PDB entry is obsolete and replaced by 4qky |
| caption="2qdz, resolution 3.15Å" />
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| '''Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family'''<br />
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| ==Overview==
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| In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins, of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB), superfamily are essential components of protein transport machineries. The, TpsB transporter FhaC mediates the secretion of Bordetella pertussis, filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of, FhaC. The transporter comprises a 16-stranded beta barrel that is occluded, by an N-terminal alpha helix and an extracellular loop and a periplasmic, module composed of two aligned polypeptide-transport-associated (POTRA), domains. Functional data reveal that FHA binds to the POTRA 1 domain via, its N-terminal domain and likely translocates the adhesin-repeated motifs, in an extended hairpin conformation, with folding occurring at the cell, surface. General features of the mechanism obtained here are likely to, apply throughout the superfamily.
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| ==About this Structure==
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| 2QDZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QDZ OCA].
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| ==Reference==
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| Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17702945 17702945]
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| [[Category: Bordetella pertussis]]
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| [[Category: Single protein]]
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| [[Category: Clantin, B.]]
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| [[Category: Jacob-Dubuisson, F.]]
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| [[Category: Villeret, V.]]
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| [[Category: beta barrel]]
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| [[Category: membrane]]
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| [[Category: potra domain]]
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| [[Category: protein transport]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:43:50 2008''
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This PDB entry is obsolete and replaced by 4qky
