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[[Image:TON.jpg|400px|right|thumb| The Ton System<ref name='Witty'> PMID: 12169623</ref>]] | [[Image:TON.jpg|400px|right|thumb| The Ton System<ref name='Witty'> PMID: 12169623</ref>]] | ||
==Structure== | ==Structure== | ||
The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex. | |||
==Function== | |||
The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell<ref>PMID: 17347522</ref>, and the system as a whole is known to be an energy-transducing system. Each of the three proteins involved have their separate role<ref name='Held'>PMID: 12193634</ref>. For more information, see the respective pages for TonB, ExbB and ExbD. | |||
== | The Ton system can be exploited by group B Colicins {see [[Colicin]] for more details) which include<ref name="Cascales">PMID: 17347522</ref><ref name='Davies'>PMID: 124727</ref>: | ||
*[[Colicin 5]] | |||
*[[Colicin 6]] | |||
*[[Colicin 7]] | |||
*[[Colicin 8]] | |||
*[[Colicin 9]] | |||
*[[Colicin 10]] | |||
*[[Colicin Ia]] | |||
*[[Colicin Ib]] | |||
*[[Colicin B]] | |||
*[[Colicin D]] | |||
*[[Colicin M]] | |||
*[[Colicin V]] | |||
*[[Colicin Js]] | |||
*[[Colicin Y]] | |||
It is interesting to note that the name 'Ton' comes its resistance to the T1 phage<ref name='Davies'>PMID: 124727</ref>. | |||
==Interaction of Ton proteins== | |||
Like in the [[Tol]] complex, the Ton system proteins interact with each other<ref>PMID: 9811664</ref>: | |||
# the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane. | |||
# ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction | |||
== | ==3D structures of TonB== | ||
[[TonB]] | |||
== References== | == References== | ||
<references/> | <references/> | ||
