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'''Unreleased structure'''


The entry 3qkp is ON HOLD
==Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop==
<StructureSection load='3qkp' size='340' side='right'caption='[[3qkp]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qkp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QKP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qkp OCA], [https://pdbe.org/3qkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qkp RCSB], [https://www.ebi.ac.uk/pdbsum/3qkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qkp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>


Authors: Brandao, T.A.S., Johnson, S.J., Hengge, A.C.
==See Also==
 
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
Description: Protein Tyrosine Phosphatase 1B -Apo W179F mutant with open WPD-loop
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brandao TAS]]
[[Category: Hengge AC]]
[[Category: Johnson SJ]]
Retrieved from "https://proteopedia.org/3qkp"