3qmk: Difference between revisions
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New page: '''Unreleased structure''' The entry 3qmk is ON HOLD Authors: Xue, Y., Ha, Y. Description: Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide |
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==Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide== | |||
<StructureSection load='3qmk' size='340' side='right'caption='[[3qmk]], [[Resolution|resolution]] 2.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3qmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmk OCA], [https://pdbe.org/3qmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmk RCSB], [https://www.ebi.ac.uk/pdbsum/3qmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ha Y]] | |||
[[Category: Xue Y]] | |||
Latest revision as of 10:48, 21 February 2024
Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide
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