2l5z: Difference between revisions

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[[Image:2l5z.jpg|left|200px]]


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==NMR structure of the A730 loop of the Neurospora VS ribozyme==
The line below this paragraph, containing "STRUCTURE_2l5z", creates the "Structure Box" on the page.
<StructureSection load='2l5z' size='340' side='right'caption='[[2l5z]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2l5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora Neurospora]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5Z FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5z OCA], [https://pdbe.org/2l5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5z RCSB], [https://www.ebi.ac.uk/pdbsum/2l5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5z ProSAT]</span></td></tr>
{{STRUCTURE_2l5z|  PDB=2l5z  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Neurospora VS ribozyme is a small nucleolytic ribozyme with unique primary, secondary and global tertiary structures, which displays mechanistic similarities to the hairpin ribozyme. Here, we determined the high-resolution NMR structure of a stem-loop VI fragment containing the A730 internal loop, which forms part of the active site. In the presence of magnesium ions, the A730 loop adopts a structure that is consistent with existing biochemical data and most likely reflects its conformation in the VS ribozyme prior to docking with the cleavage site internal loop. Interestingly, the A730 loop adopts an S-turn motif that is also present in loop B within the hairpin ribozyme active site. The S-turn appears necessary to expose the Watson-Crick edge of a catalytically important residue (A756) so that it can fulfill its role in catalysis. The A730 loop and the cleavage site loop of the VS ribozyme display structural similarities to internal loops found in the active site of the hairpin ribozyme. These similarities provided a rationale to build a model of the VS ribozyme active site based on the crystal structure of the hairpin ribozyme.


===NMR structure of the A730 loop of the Neurospora VS ribozyme===
NMR structure of the A730 loop of the Neurospora VS ribozyme: insights into the formation of the active site.,Desjardins G, Bonneau E, Girard N, Boisbouvier J, Legault P Nucleic Acids Res. 2011 Jan 25. PMID:21266483<ref>PMID:21266483</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2l5z" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_21266483}}, adds the Publication Abstract to the page
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 21266483 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21266483}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2l5z]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5Z OCA].
[[Category: Neurospora]]
 
[[Category: Boisbouvier J]]
==Reference==
[[Category: Bonneau E]]
<ref group="xtra">PMID:21266483</ref><references group="xtra"/>
[[Category: Desjardins G]]
[[Category: Boisbouvier, J.]]
[[Category: Girard N]]
[[Category: Bonneau, E.]]
[[Category: Legault P]]
[[Category: Desjardins, G.]]
[[Category: Girard, N.]]
[[Category: Legault, P.]]

Latest revision as of 05:39, 15 May 2024

NMR structure of the A730 loop of the Neurospora VS ribozyme

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