3q2s: Difference between revisions
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==Crystal Structure of CFIm68 RRM/CFIm25 complex== | |||
<StructureSection load='3q2s' size='340' side='right'caption='[[3q2s]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3q2s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2s OCA], [https://pdbe.org/3q2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2s RCSB], [https://www.ebi.ac.uk/pdbsum/3q2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2s ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref> | |||
== References == | |||
<references/> | |||
< | __TOC__ | ||
</StructureSection> | |||
== | |||
[[3q2s]] is a 4 chain structure with sequence from [ | |||
== | |||
< | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Yang | [[Category: Large Structures]] | ||
[[Category: Coseno M]] | |||
[[Category: Doublie S]] | |||
[[Category: Gilmartin GM]] | |||
[[Category: Yang Q]] | |||