Human Follicle-Stimulating Hormone Complexed with its Receptor: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_1xwd", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the P... |
No edit summary |
||
| (48 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
{{Article under development}} | |||
NEEDS UPDATING TO INCLUDE [[4ay9]]. | |||
[[Image:1xwd polyview3d.png|left|400px]] | |||
===Crystal Structure of Human Follicle-Stimulating Hormone Complexed with its Receptor=== | |||
<!-- | |||
The line below this paragraph, {{ABSTRACT_PUBMED_15662415}}, adds the Publication Abstract to the page | |||
(as it appears on PubMed at http://www.pubmed.gov), where 15662415 is the PubMed ID number. | |||
--> | |||
{{ABSTRACT_PUBMED_15662415}} | |||
==Disease== | |||
<!-- | <!-- | ||
The line below this paragraph, containing "STRUCTURE_1xwd", creates the "Structure Box" on the page. | The line below this paragraph, containing "STRUCTURE_1xwd", creates the "Structure Box" on the page. | ||
| Line 9: | Line 17: | ||
--> | --> | ||
<!--TURNS OUT IF YOU SET PDB TO NOTHING YOU CAN GET RID OF COORDINATES BLOCK AND HAVE BOLD CAPTION!!--> | <!--TURNS OUT IF YOU SET PDB TO NOTHING YOU CAN GET RID OF COORDINATES BLOCK AND HAVE BOLD CAPTION!!--> | ||
<table width= | <table width=380' align='right' cellpadding='0'><tr><td bgcolor='#eeeeee'>{{Structure | ||
|PDB= | |PDB= | ||
|SIZE=350|SCENE= | |SIZE=350|SCENE=Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4|CAPTION= Glycosylated FSH complex with acetylamino-deoxy-pyranose and sulfate binding to the leucine-rich domain of Follicle Stimulating Hormone Receptor ([[1fl7]] morphing to [[1xwd]], [[resolution]] 2.92Å) | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= | ||
| Line 21: | Line 29: | ||
|COORDINATES= | |COORDINATES= | ||
}}</td></tr><tr><td bgcolor='#eeeeee'><center> | }}</td></tr><tr><td bgcolor='#eeeeee'><center> | ||
{{Button ColorReceptorLeucine}} <scene name=' | {{Button ColorReceptorLeucine}} <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4'>Initial scene</scene> | ||
</center></td></tr></table> | </center></td></tr></table> | ||
Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]] | Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]] | ||
| Line 41: | Line 37: | ||
The leucine-rich domain of the receptor <scene name=' | The leucine-rich domain of the receptor <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorphleu/4'>has a characteristic bowed shape due to harboring a series of leucine-rich repeats</scene>; [[Leucine-rich repeat|leucine-rich repeats]] often are horseshoe- or arc-shaped.<br\> | ||
{{Button Toggle AnimationOnPause}}<br\> | |||
{{Link Toggle WireframeOnOff}}<br\> | |||
{{Link Toggle FancyCartoonHighQualityView}}<br\> | |||
Add about cysteine-knot. <br\> | |||
Add about seat belt.<br\> | |||
Keep in mind this is just the leucine-rich repeat, amino-terminal portion of the receptor and that in the full receptor structure part of the chain also forms a [[G protein-coupled receptor]] and a brief intracellular domain at the C-terminus. | |||
== | ==References== | ||
<ref group="xtra">PMID:15662415</ref><references group="xtra"/> | <ref group="xtra">PMID:15662415</ref><references group="xtra"/> | ||
<ref group="xtra">PMID:22802634 </ref><references group="xtra"/> | |||
==See also== | ==See also== | ||
*[[Leucine-rich repeat|Leucine-rich repeat proteins]] | *[[Leucine-rich repeat|Leucine-rich repeat proteins]] | ||
* [[Hormone]] | |||
* [[Membrane proteins]] | |||
*[[Receptor]] | |||
*[[Transmembrane (cell surface) receptors]] | |||
*[[G protein-coupled receptors]] | |||
* [[1hcn]] - human chorionic gonadotropin placental hormone | |||
* [[1hrp]] - human chorionic gonadotropin placental hormone | |||
* [[1hd4]] - human chorionic gonadotropin placental hormone alpha subunit | |||
* [[3g04]] - Human thyroid-stimulating hormone receptor in complex with a thyroid-stimulating autoantibody | |||
==3D structures of follicle-stimulating hormone== | |||
See [[Follicle-stimulating hormone]] | |||
==External Resources== | |||
* [http://www.ssfa-gphr.de/index.php Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors] | |||
* [http://gris.ulb.ac.be/ GRIS: Glycoprotein-hormone Receptors Information System] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
