Human Follicle-Stimulating Hormone Complexed with its Receptor: Difference between revisions
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[[Image:1xwd polyview3d.png|left| | {{Article under development}} | ||
NEEDS UPDATING TO INCLUDE [[4ay9]]. | |||
[[Image:1xwd polyview3d.png|left|400px]] | |||
===Crystal Structure of Human Follicle-Stimulating Hormone Complexed with its Receptor=== | ===Crystal Structure of Human Follicle-Stimulating Hormone Complexed with its Receptor=== | ||
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<!--TURNS OUT IF YOU SET PDB TO NOTHING YOU CAN GET RID OF COORDINATES BLOCK AND HAVE BOLD CAPTION!!--> | <!--TURNS OUT IF YOU SET PDB TO NOTHING YOU CAN GET RID OF COORDINATES BLOCK AND HAVE BOLD CAPTION!!--> | ||
<table width= | <table width=380' align='right' cellpadding='0'><tr><td bgcolor='#eeeeee'>{{Structure | ||
|PDB= | |PDB= | ||
|SIZE=350|SCENE= | |SIZE=350|SCENE=Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4|CAPTION= Glycosylated FSH complex with acetylamino-deoxy-pyranose and sulfate binding to the leucine-rich domain of Follicle Stimulating Hormone Receptor ([[1fl7]] morphing to [[1xwd]], [[resolution]] 2.92Å) | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= | ||
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|COORDINATES= | |COORDINATES= | ||
}}</td></tr><tr><td bgcolor='#eeeeee'><center> | }}</td></tr><tr><td bgcolor='#eeeeee'><center> | ||
{{Button ColorReceptorLeucine}} <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/ | {{Button ColorReceptorLeucine}} <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4'>Initial scene</scene> | ||
</center></td></tr></table> | </center></td></tr></table> | ||
Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]] | Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]] | ||
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The leucine-rich domain of the receptor <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorphleu/ | The leucine-rich domain of the receptor <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorphleu/4'>has a characteristic bowed shape due to harboring a series of leucine-rich repeats</scene>; [[Leucine-rich repeat|leucine-rich repeats]] often are horseshoe- or arc-shaped.<br\> | ||
{{Button Toggle AnimationOnPause}}<br\> | {{Button Toggle AnimationOnPause}}<br\> | ||
{{Link Toggle FancyCartoonHighQualityView}} | {{Link Toggle WireframeOnOff}}<br\> | ||
{{Link Toggle FancyCartoonHighQualityView}}<br\> | |||
== | Add about cysteine-knot. <br\> | ||
Add about seat belt.<br\> | |||
Keep in mind this is just the leucine-rich repeat, amino-terminal portion of the receptor and that in the full receptor structure part of the chain also forms a [[G protein-coupled receptor]] and a brief intracellular domain at the C-terminus. | |||
==References== | |||
<ref group="xtra">PMID:15662415</ref><references group="xtra"/> | <ref group="xtra">PMID:15662415</ref><references group="xtra"/> | ||
<ref group="xtra">PMID:22802634 </ref><references group="xtra"/> | |||
==See also== | ==See also== | ||
*[[Leucine-rich repeat|Leucine-rich repeat proteins]] | *[[Leucine-rich repeat|Leucine-rich repeat proteins]] | ||
* [[Hormone]] | |||
* [[Membrane proteins]] | |||
*[[Receptor]] | |||
*[[Transmembrane (cell surface) receptors]] | |||
*[[G protein-coupled receptors]] | |||
* [[1hcn]] - human chorionic gonadotropin placental hormone | |||
* [[1hrp]] - human chorionic gonadotropin placental hormone | |||
* [[1hd4]] - human chorionic gonadotropin placental hormone alpha subunit | |||
* [[3g04]] - Human thyroid-stimulating hormone receptor in complex with a thyroid-stimulating autoantibody | |||
==3D structures of follicle-stimulating hormone== | |||
See [[Follicle-stimulating hormone]] | |||
==External Resources== | |||
* [http://www.ssfa-gphr.de/index.php Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors] | |||
* [http://gris.ulb.ac.be/ GRIS: Glycoprotein-hormone Receptors Information System] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Latest revision as of 14:30, 31 May 2021
For the date when the most recent work on this article was done, click on the history tab above. |
NEEDS UPDATING TO INCLUDE 4ay9.
Crystal Structure of Human Follicle-Stimulating Hormone Complexed with its Receptor
Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian functions. We present here the 2.9-A-resolution structure of a partially deglycosylated complex of human FSH bound to the extracellular hormone-binding domain of its receptor (FSHR(HB)). The hormone is bound in a hand-clasp fashion to an elongated, curved receptor. The buried interface of the complex is large (2,600 A2) and has a high charge density. Our analysis suggests that all glycoprotein hormones bind to their receptors in this mode and that binding specificity is mediated by key interaction sites involving both the common alpha- and hormone-specific beta-subunits. On binding, FSH undergoes a concerted conformational change that affects protruding loops implicated in receptor activation. The FSH-FSHR(HB) complexes form dimers in the crystal and at high concentrations in solution. Such dimers may participate in transmembrane signal transduction.
Structure of human follicle-stimulating hormone in complex with its receptor., Fan QR, Hendrickson WA, Nature. 2005 Jan 20;433(7023):269-77. PMID:15662415
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Disease
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Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[136530], Ovarian dysgenesis 1 OMIM:[136435], Ovarian hyperstimulation syndrome OMIM:[136435], Ovarian response to FSH stimulation OMIM:[136435], Ovarian sex cord tumors OMIM:[136435]
About this Structure
1XWD is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
The leucine-rich domain of the receptor has a characteristic bowed shape due to harboring a series of leucine-rich repeats; leucine-rich repeats often are horseshoe- or arc-shaped.<br\>
<br\>
<br\>
<br\>
Add about cysteine-knot. <br\> Add about seat belt.<br\> Keep in mind this is just the leucine-rich repeat, amino-terminal portion of the receptor and that in the full receptor structure part of the chain also forms a G protein-coupled receptor and a brief intracellular domain at the C-terminus.
References
- Fan QR, Hendrickson WA. Structure of human follicle-stimulating hormone in complex with its receptor. Nature. 2005 Jan 20;433(7023):269-77. PMID:15662415 doi:10.1038/nature03206
- Jiang X, Liu H, Chen X, Chen PH, Fischer D, Sriraman V, Yu HN, Arkinstall S, He X. Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12491-6. Epub 2012 Jul 16. PMID:22802634 doi:10.1073/pnas.1206643109
See also
- Leucine-rich repeat proteins
- Hormone
- Membrane proteins
- Receptor
- Transmembrane (cell surface) receptors
- G protein-coupled receptors
- 1hcn - human chorionic gonadotropin placental hormone
- 1hrp - human chorionic gonadotropin placental hormone
- 1hd4 - human chorionic gonadotropin placental hormone alpha subunit
- 3g04 - Human thyroid-stimulating hormone receptor in complex with a thyroid-stimulating autoantibody
3D structures of follicle-stimulating hormone
See Follicle-stimulating hormone
External Resources
- Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors
- GRIS: Glycoprotein-hormone Receptors Information System
Page originally seeded at 1xwd by OCA on Tue Feb 17 21:34:49 2009
