3pim: Difference between revisions

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[[Image:3pim.jpg|left|200px]]


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==Crystal structure of Mxr1 from Saccharomyces cerevisiae in unusual oxidized form==
The line below this paragraph, containing "STRUCTURE_3pim", creates the "Structure Box" on the page.
<StructureSection load='3pim' size='340' side='right'caption='[[3pim]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3pim]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PIM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pim OCA], [https://pdbe.org/3pim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pim RCSB], [https://www.ebi.ac.uk/pdbsum/3pim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pim ProSAT]</span></td></tr>
{{STRUCTURE_3pim|  PDB=3pim  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MSRA_YEAST MSRA_YEAST] Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The methionine S-sulfoxide reductase MsrA catalyzes the reduction of methionine sulfoxide, a ubiquitous reaction depending on the thioredoxin system. To investigate interactions between MsrA and thioredoxin (Trx), we determined the crystal structures of yeast MsrA/Mxr1 in their reduced, oxidized, and Trx2-complexed forms, at 2.03, 1.90, and 2.70 A, respectively. Comparative structure analysis revealed significant conformational changes of the three loops, which form a plastic "cushion" to harbor the electron donor Trx2. The flexible C-terminal loop enabled Mxr1 to access the methionine sulfoxide on various protein substrates. Moreover, the plasticity of the Trx binding site on Mxr1 provides structural insights into the recognition of diverse substrates by a universal catalytic motif of Trx.


===Crystal structure of Mxr1 from Saccharomyces cerevisiae in unusual oxidized form===
Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1.,Ma XX, Guo PC, Shi WW, Luo M, Tan XF, Chen Y, Zhou CZ J Biol Chem. 2011 Apr 15;286(15):13430-7. Epub 2011 Feb 23. PMID:21345799<ref>PMID:21345799</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
[[3pim]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIM OCA].
<div class="pdbe-citations 3pim" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Chen, Y.]]
[[Category: Chen Y]]
[[Category: Guo, P C.]]
[[Category: Guo PC]]
[[Category: Luo, M.]]
[[Category: Luo M]]
[[Category: Ma, X X.]]
[[Category: Ma XX]]
[[Category: Shi, W W.]]
[[Category: Shi WW]]
[[Category: Tan, X F.]]
[[Category: Tan XF]]
[[Category: Zhou, C Z.]]
[[Category: Zhou CZ]]
Retrieved from "https://proteopedia.org/3pim"