Sandbox 350: Difference between revisions

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1. Amino acid specificity: residues <scene name='Sandbox_250/Ache_fas2/14'>Thr8, Arg27 and Met33</scene> are located on two of the three fingers of FAS-II. When FAS-II <scene name='Sandbox_250/Ache_fas2/17'>binds</scene> to AChE, Arg27 and Met33 interact with Trp279 part of the PAS, while Thr8 interact with Tyr70, also part of the PAS.

2. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death.\

2. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death.

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[[Image:Smart Teams photo 5.jpg|right|120px]]

SMART Teams (Students Modeling A Research Topic) is a science outreach program developed by the MSOE Center for BioMolecular Modeling. In this program, teams of high school students work with a local resarch lab to design and build a physical model of a protein that is being investigated by the lab. The goal of the SMART Team program is to introduce students to the real world of science --- as it exists in a local research lab. The development of this program was supported by grants from the NIH-NCRR SEPA program (Science Education Partnership Award) and an HHMI Precollege Science Education Award. For more information about this program, visit the [[SMART Teams|SMART Teams Proteopedia home page]] or visit the CBM web site at [http://www.rpc.msoe.edu/cbm www.rpc.msoe.edu/cbm].

SMART Teams (Students Modeling A Research Topic) is a science outreach program developed by the MSOE Center for BioMolecular Modeling. In this program, teams of high school students work with a local resarch lab to design and build a physical model of a protein that is being investigated by the lab. The goal of the SMART Team program is to introduce students to the real world of science --- as it exists in a local research lab. The development of this program was supported by grants from the NIH-NCRR SEPA program (Science Education Partnership Award) and an HHMI Precollege Science Education Award. For more information about this program, visit the [[Group:SMART:Teams|SMART Teams Proteopedia home page]] or visit the CBM web site at [http://www.rpc.msoe.edu/cbm www.rpc.msoe.edu/cbm].

Sandbox 350: Difference between revisions

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@@ Line 163: / Line 163: @@
 . Amino acid specificity: residues <scene name='Sandbox_250/Ache_fas2/14'>Thr8, Arg27 and Met33</scene> are located on two of the three fingers of FAS-II. When FAS-II <scene name='Sandbox_250/Ache_fas2/17'>binds</scene> to AChE, Arg27 and Met33 interact with Trp279 part of the PAS, while Thr8 interact with Tyr70, also part of the PAS.
-. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death.\
+. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death.
+<scene name='Sandbox_350/Ache_surface_no_fas/1'>No_Fas</scene>
 <scene name='Sandbox_350/Ache_surface_with_fas/1'>yes_fas</scene>
@@ Line 234: / Line 235: @@
 [[Image:Smart Teams photo 5.jpg|right|120px]]
-<font color = 'red'>SMART  Teams (S</font>tudents <font color = 'red'>M</font>odeling <font color = 'red'>A</font> <font color = 'red'>R</font>esearch <font color = 'red'>T</font>opic) is a science outreach program developed by the MSOE Center for BioMolecular Modeling.  In this program, teams of high school students work with a local resarch lab to design and build a physical model of a protein that is being investigated by the lab.  The goal of the SMART Team program is to introduce students to the real world of science --- as it exists in a local research lab.  The development of this program was supported by grants from the NIH-NCRR SEPA program (Science Education Partnership Award) and an HHMI Precollege Science Education Award.  For more information about this program,  visit the [[SMART Teams|SMART Teams Proteopedia home page]] or visit the CBM web site at [http://www.rpc.msoe.edu/cbm www.rpc.msoe.edu/cbm].
+<font color = 'red'>SMART  Teams (S</font>tudents <font color = 'red'>M</font>odeling <font color = 'red'>A</font> <font color = 'red'>R</font>esearch <font color = 'red'>T</font>opic) is a science outreach program developed by the MSOE Center for BioMolecular Modeling.  In this program, teams of high school students work with a local resarch lab to design and build a physical model of a protein that is being investigated by the lab.  The goal of the SMART Team program is to introduce students to the real world of science --- as it exists in a local research lab.  The development of this program was supported by grants from the NIH-NCRR SEPA program (Science Education Partnership Award) and an HHMI Precollege Science Education Award.  For more information about this program,  visit the [[Group:SMART:Teams|SMART Teams Proteopedia home page]] or visit the CBM web site at [http://www.rpc.msoe.edu/cbm www.rpc.msoe.edu/cbm].