3o8h: Difference between revisions

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[[Image:3o8h.png|left|200px]]


<!--
==EthR from Mycobacterium tuberculosis in complex with compound BDM14950==
The line below this paragraph, containing "STRUCTURE_3o8h", creates the "Structure Box" on the page.
<StructureSection load='3o8h' size='340' side='right'caption='[[3o8h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3o8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O8H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O8H:4-IODO-N-[(1-{2-OXO-2-[4-(3-THIOPHEN-2-YL-1,2,4-OXADIAZOL-5-YL)PIPERIDIN-1-YL]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL]BENZENESULFONAMIDE'>O8H</scene></td></tr>
{{STRUCTURE_3o8h| PDB=3o8h |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o8h OCA], [https://pdbe.org/3o8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o8h RCSB], [https://www.ebi.ac.uk/pdbsum/3o8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o8h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/3o8h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o8h ConSurf].
<div style="clear:both"></div>


===EthR from Mycobacterium tuberculosis in complex with compound BDM14950===
==See Also==
 
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_20704273}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 20704273 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_20704273}}
 
==About this Structure==
[[3o8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8H OCA].
 
==Reference==
<ref group="xtra">PMID:20704273</ref><references group="xtra"/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Baulard, A.]]
[[Category: Baulard A]]
[[Category: Deprez, B.]]
[[Category: Deprez B]]
[[Category: Desroses, M.]]
[[Category: Desroses M]]
[[Category: Diri, B.]]
[[Category: Diri B]]
[[Category: Lens, Z.]]
[[Category: Lens Z]]
[[Category: Locht, C.]]
[[Category: Locht C]]
[[Category: Rucktooa, P.]]
[[Category: Rucktooa P]]
[[Category: Toto, P.]]
[[Category: Toto P]]
[[Category: Villeret, V.]]
[[Category: Villeret V]]
[[Category: Willand, N.]]
[[Category: Willand N]]

Latest revision as of 10:33, 21 February 2024

EthR from Mycobacterium tuberculosis in complex with compound BDM14950

3o8h, resolution 1.90Å

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