3qmk: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 3qmk is ~~ON HOLD until Paper Publication~~

==Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide==

~~Authors~~: ~~Xue~~, Y., Ha, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[3qmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMK OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3QMK FirstGlance].

~~Description~~: ~~Crystal structure~~ of the ~~E2 domain~~ of ~~APLP1 in complex with heparin hexasaccharide~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3qmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmk OCA], [https://pdbe.org/3qmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmk RCSB], [https://www.ebi.ac.uk/pdbsum/3qmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmk ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ha Y]]

[[Category: Xue Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3qmk is ON HOLD  until Paper Publication
+==Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide==
+<StructureSection load='3qmk' size='340' side='right'caption='[[3qmk]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
-Authors: Xue, Y., Ha, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3qmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMK FirstGlance]. <br>
-Description: Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmk OCA], [https://pdbe.org/3qmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmk RCSB], [https://www.ebi.ac.uk/pdbsum/3qmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmk ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.  The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ha Y]]
+[[Category: Xue Y]]