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[[Image:2ebw.gif|left|200px]]<br /><applet load="2ebw" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2ebw" />
'''Solution structure of the BRCT domain from human DNA repair protein REV1'''<br />


==About this Structure==
==Solution structure of the BRCT domain from human DNA repair protein REV1==
2EBW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBW OCA].  
<StructureSection load='2ebw' size='340' side='right'caption='[[2ebw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ebw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebw OCA], [https://pdbe.org/2ebw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebw RCSB], [https://www.ebi.ac.uk/pdbsum/2ebw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebw ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebw TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2ebw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebw ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Nagashima, T.]]
[[Category: Nagashima T]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: a/b/a 3 layers]]
[[Category: dna polymerase zeta]]
[[Category: dna replication]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: parallel beta-sheet]]
[[Category: pcna]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: tls]]
[[Category: transferase]]
[[Category: translession synthesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:10:08 2008''
Retrieved from "https://proteopedia.org/2ebw"