3q5i: Difference between revisions
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==Crystal Structure of PBANKA_031420== | |||
<StructureSection load='3q5i' size='340' side='right'caption='[[3q5i]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3q5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q5I FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q5i OCA], [https://pdbe.org/3q5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q5i RCSB], [https://www.ebi.ac.uk/pdbsum/3q5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q5i ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CDPK1_PLABA CDPK1_PLABA] Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (By similarity). During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK4 and CDPK5 (PubMed:32866196). In the mosquito midgut and during the last stage of male gamete exflagellation, may play a role in the rupture of the host erythrocyte membrane (PubMed:22817984). In the mosquito midgut, required for the differentiation of the zygote into the ookinete by promoting the translational activation of a subset of repressed mRNAs; these mRNAs are kept repressed in the zygote by the DOZI- or CITH-containing mRNP complexes (PubMed:22817984, PubMed:24265753). Dispensable during the asexual blood stage (PubMed:24265753).[UniProtKB:P62344]<ref>PMID:22817984</ref> <ref>PMID:24265753</ref> <ref>PMID:32866196</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Plasmodium berghei]] | |||
[[Category: Amani M]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Cossar D]] | |||
[[Category: Crombet L]] | |||
[[Category: Edwards AM]] | |||
[[Category: Hassani A]] | |||
[[Category: Hui R]] | |||
[[Category: Hutchinson A]] | |||
[[Category: Neculai AM]] | |||
[[Category: Panico E]] | |||
[[Category: Sullivan H]] | |||
[[Category: Vedadi M]] | |||
[[Category: Weigelt J]] | |||
[[Category: Wernimont AK]] | |||
Latest revision as of 11:33, 14 March 2024
Crystal Structure of PBANKA_031420
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