3qwl: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 3qwl is ON HOLD Authors: Guan, X., Tempel, W., Tong, Y., Wernimont, A.K., Landry, R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Par... |
No edit summary |
||
| (7 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of human TBC1 domain family member 7== | |||
<StructureSection load='3qwl' size='340' side='right'caption='[[3qwl]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3qwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwl OCA], [https://pdbe.org/3qwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwl RCSB], [https://www.ebi.ac.uk/pdbsum/3qwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Edwards AM]] | |||
[[Category: Guan X]] | |||
[[Category: Landry R]] | |||
[[Category: Park H]] | |||
[[Category: Tempel W]] | |||
[[Category: Tong Y]] | |||
[[Category: Weigelt J]] | |||
[[Category: Wernimont AK]] | |||
Latest revision as of 10:50, 21 February 2024
Crystal structure of human TBC1 domain family member 7
| ||||||||||||
