3qwv: Difference between revisions
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New page: '''Unreleased structure''' The entry 3qwv is ON HOLD Authors: Jiang, Y., Sirinupong, N., Brunzelle, J., Yang, Z. Description: Crystal structure of histone lysine methyltransferase SmyD... |
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==Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy== | |||
<StructureSection load='3qwv' size='340' side='right'caption='[[3qwv]], [[Resolution|resolution]] 2.03Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3qwv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwv OCA], [https://pdbe.org/3qwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwv RCSB], [https://www.ebi.ac.uk/pdbsum/3qwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SMYD2_MOUSE SMYD2_MOUSE] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.<ref>PMID:16805913</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Brunzelle J]] | |||
[[Category: Jiang Y]] | |||
[[Category: Sirinupong N]] | |||
[[Category: Yang Z]] | |||
Latest revision as of 10:50, 21 February 2024
Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy
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