2jfk: Difference between revisions

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[[Image:2jfk.gif|left|200px]]<br />
<applet load="2jfk" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2jfk, resolution 2.40&Aring;" />
'''STRUCTURE OF THE MAT DOMAIN OF HUMAN FAS WITH MALONYL-COA'''<br />


==About this Structure==
==Structure of the MAT domain of human FAS with malonyl-CoA==
2JFK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with COA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Fatty-acid_synthase Fatty-acid synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.85 2.3.1.85]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JFK OCA]].  
<StructureSection load='2jfk' size='340' side='right'caption='[[2jfk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
[[Category: Fatty-acid synthase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2jfk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MCS:MALONYL+CYSTEINE'>MCS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfk OCA], [https://pdbe.org/2jfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfk RCSB], [https://www.ebi.ac.uk/pdbsum/2jfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jfk ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.H.]]
[[Category: Arrowsmith CH]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi G]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Hozjan, V.]]
[[Category: Hozjan V]]
[[Category: Kavanagh, K.]]
[[Category: Kavanagh K]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Rojkova, A.]]
[[Category: Rojkova A]]
[[Category: Smith, S.]]
[[Category: Smith S]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Watt, S.]]
[[Category: Watt S]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Wu, X.]]
[[Category: Wu X]]
[[Category: COA]]
[[Category: acetyl transferase]]
[[Category: acetylation]]
[[Category: fatty acid biosynthesis]]
[[Category: fatty acid synthase]]
[[Category: hydrolase]]
[[Category: lipid synthesis]]
[[Category: lyase]]
[[Category: malonyl transferase]]
[[Category: malonylation]]
[[Category: mat domain]]
[[Category: multifunctional enzyme]]
[[Category: nad]]
[[Category: nadp]]
[[Category: oxidoreductase]]
[[Category: phosphopantetheine]]
[[Category: phosphorylation]]
[[Category: pyridoxal phosphate]]
[[Category: transferase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:40:33 2007''
Retrieved from "https://proteopedia.org/2jfk"