2x3a: Difference between revisions

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[[Image:2x3a.png|left|200px]]


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==AsaP1 inactive mutant E294Q, an extracellular toxic zinc metalloendopeptidase==
The line below this paragraph, containing "STRUCTURE_2x3a", creates the "Structure Box" on the page.
<StructureSection load='2x3a' size='340' side='right'caption='[[2x3a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2x3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_salmonicida_subsp._achromogenes Aeromonas salmonicida subsp. achromogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X3A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2x3a|  PDB=2x3a  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x3a OCA], [https://pdbe.org/2x3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x3a RCSB], [https://www.ebi.ac.uk/pdbsum/2x3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x3a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8GMV9_AERSA Q8GMV9_AERSA]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Gram-negative bacterium Aeromonas salmonicida is a fish pathogen for various fish species worldwide. Aeromonas salmonicida subsp. achromogenes produces the extracellular, toxic zinc endopeptidase AsaP1. Crystal structure analyses at 2.0 A resolution of two proteolytically inactive AsaP1 variants show the polypeptide folding of the protease domain and the propeptide domain. These first crystal structure analyses of a precursor of a deuterolysin-like aspzincin protease provide insights into propeptide function, and specific substrate binding. A lysine side chain of the propeptide binds in the hydrophobic S1'-pocket interacting with three carboxylate side chains. An AsaP1 variant with a lysine to alanine exchange identifies the chaperone function of the propeptide.


===ASAP1 INACTIVE MUTANT E294Q, AN EXTRACELLULAR TOXIC ZINC METALLOENDOPEPTIDASE===
Structural evidence of intramolecular propeptide inhibition of the aspzincin metalloendopeptidase AsaP1.,Bogdanovic X, Palm GJ, Schwenteit J, Singh RK, Gudmundsdottir BK, Hinrichs W FEBS Lett. 2016 Aug 16. doi: 10.1002/1873-3468.12356. PMID:27528449<ref>PMID:27528449</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_19574642}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2x3a" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19574642 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19574642}}
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</StructureSection>
==About this Structure==
[[2x3a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeromonas_salmonicida_subsp._achromogenes Aeromonas salmonicida subsp. achromogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X3A OCA].
 
==Reference==
<ref group="xtra">PMID:19574642</ref><ref group="xtra">PMID:18952802</ref><references group="xtra"/>
[[Category: Aeromonas salmonicida subsp. achromogenes]]
[[Category: Aeromonas salmonicida subsp. achromogenes]]
[[Category: Deuterolysin]]
[[Category: Large Structures]]
[[Category: Bogdanovic, X.]]
[[Category: Bogdanovic X]]
[[Category: Hinrichs, W.]]
[[Category: Hinrichs W]]
[[Category: Palm, G J.]]
[[Category: Palm GJ]]
[[Category: Singh, R K.]]
[[Category: Singh RK]]
Retrieved from "https://proteopedia.org/2x3a"