1hch: Difference between revisions

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[[Image:1hch.png|left|200px]]


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==Structure of horseradish peroxidase C1A compound I==
The line below this paragraph, containing "STRUCTURE_1hch", creates the "Structure Box" on the page.
<StructureSection load='1hch' size='340' side='right'caption='[[1hch]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hch]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HCH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene></td></tr>
{{STRUCTURE_1hch|  PDB=1hch  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hch OCA], [https://pdbe.org/1hch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hch RCSB], [https://www.ebi.ac.uk/pdbsum/1hch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hch ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/1hch_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hch ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A molecular description of oxygen and peroxide activation in biological systems is difficult, because electrons liberated during X-ray data collection reduce the active centres of redox enzymes catalysing these reactions. Here we describe an effective strategy to obtain crystal structures for high-valency redox intermediates and present a three-dimensional movie of the X-ray-driven catalytic reduction of a bound dioxygen species in horseradish peroxidase (HRP). We also describe separate experiments in which high-resolution structures could be obtained for all five oxidation states of HRP, showing such structures with preserved redox states for the first time.


===STRUCTURE OF HORSERADISH PEROXIDASE C1A COMPOUND I===
The catalytic pathway of horseradish peroxidase at high resolution.,Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J Nature. 2002 May 23;417(6887):463-8. PMID:12024218<ref>PMID:12024218</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1hch" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_12024218}}, adds the Publication Abstract to the page
*[[Horseradish peroxidase|Horseradish peroxidase]]
(as it appears on PubMed at http://www.pubmed.gov), where 12024218 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_12024218}}
__TOC__
 
</StructureSection>
==About this Structure==
[[1hch]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCH OCA].
 
==Reference==
<ref group="xtra">PMID:12024218</ref><ref group="xtra">PMID:10574977</ref><ref group="xtra">PMID:9406554</ref><ref group="xtra">PMID:2198290</ref><references group="xtra"/>
[[Category: Armoracia rusticana]]
[[Category: Armoracia rusticana]]
[[Category: Peroxidase]]
[[Category: Large Structures]]
[[Category: Berglund, G I.]]
[[Category: Berglund GI]]
[[Category: Carlsson, G H.]]
[[Category: Carlsson GH]]
[[Category: Hajdu, J.]]
[[Category: Hajdu J]]
[[Category: Henriksen, A.]]
[[Category: Henriksen A]]
[[Category: Smith, A T.]]
[[Category: Smith AT]]
[[Category: Szoke, H.]]
[[Category: Szoke H]]
[[Category: Catalytic intermediate]]
[[Category: Compound i]]
[[Category: Horseradish]]
[[Category: Oxidoreductase]]
[[Category: Peroxidase]]
Retrieved from "https://proteopedia.org/1hch"