3hxa: Difference between revisions

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[[Image:3hxa.png|left|200px]]


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==Crystal Structure of DCoH1Thr51Ser==
The line below this paragraph, containing "STRUCTURE_3hxa", creates the "Structure Box" on the page.
<StructureSection load='3hxa' size='340' side='right'caption='[[3hxa]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hxa]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HXA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3hxa|  PDB=3hxa  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hxa OCA], [https://pdbe.org/3hxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hxa RCSB], [https://www.ebi.ac.uk/pdbsum/3hxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hxa ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of DCoH1Thr51Ser===
== Function ==
 
[https://www.uniprot.org/uniprot/PHS_RAT PHS_RAT] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.<ref>PMID:1763325</ref> <ref>PMID:8444860</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_7725101}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 7725101 is the PubMed ID number.
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hxa_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_7725101}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[3hxa]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXA OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hxa ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:7725101</ref><ref group="xtra">PMID:15182178</ref><references group="xtra"/>
<references/>
[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Jones, C N.]]
[[Category: Jones CN]]
[[Category: Rho, H Y.]]
[[Category: Rho HY]]
[[Category: Rose, R B.]]
[[Category: Rose RB]]
[[Category: Alpha and beta structure]]
[[Category: Lyase]]
[[Category: Nucleus]]
[[Category: Tetrahydrobiopterin biosynthesis]]

Latest revision as of 10:02, 21 February 2024

Crystal Structure of DCoH1Thr51Ser

3hxa, resolution 1.80Å

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