2p2k: Difference between revisions
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==Crystal structure of a lectin from Canavalia gladiata seeds (CGL) in complex with man1-4man-OMe== | |||
<StructureSection load='2p2k' size='340' side='right'caption='[[2p2k]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2p2k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P2K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p2k OCA], [https://pdbe.org/2p2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p2k RCSB], [https://www.ebi.ac.uk/pdbsum/2p2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p2k ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/2p2k_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p2k ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Concanavalin 3D structures|Concanavalin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[ | |||
== | |||
< | |||
[[Category: Canavalia gladiata]] | [[Category: Canavalia gladiata]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Benevides | [[Category: Benevides GB]] | ||
[[Category: Bezerra | [[Category: Bezerra GA]] | ||
[[Category: Cavada | [[Category: Cavada BS]] | ||
[[Category: Delatorre | [[Category: Delatorre P]] | ||
[[Category: Moreno | [[Category: Moreno FBMB]] | ||
[[Category: Oliveira | [[Category: Oliveira TM]] | ||
[[Category: Rocha | [[Category: Rocha BAM]] | ||
[[Category: Souza | [[Category: Souza EP]] | ||
[[Category: De Azevedo Jr WF]] | |||
