2kxn: Difference between revisions

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[[Image:2kxn.jpg|left|200px]]


<!--
==NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA==
The line below this paragraph, containing "STRUCTURE_2kxn", creates the "Structure Box" on the page.
<StructureSection load='2kxn' size='340' side='right'caption='[[2kxn]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kxn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxn OCA], [https://pdbe.org/2kxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxn RCSB], [https://www.ebi.ac.uk/pdbsum/2kxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxn ProSAT]</span></td></tr>
{{STRUCTURE_2kxn|  PDB=2kxn  |  SCENE=  }}
</table>
 
== Function ==
===NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA===
[https://www.uniprot.org/uniprot/TRA2B_HUMAN TRA2B_HUMAN] Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.<ref>PMID:9546399</ref> <ref>PMID:12165565</ref> <ref>PMID:12761049</ref> <ref>PMID:15009664</ref>
 
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2kxn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXN OCA].  
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allain, F H.T.]]
[[Category: Large Structures]]
[[Category: Benderska, N.]]
[[Category: Allain FH-T]]
[[Category: Clery, A.]]
[[Category: Benderska N]]
[[Category: Dominguez, C.]]
[[Category: Clery A]]
[[Category: Jayne, S.]]
[[Category: Dominguez C]]
[[Category: Stamm, S.]]
[[Category: Jayne S]]
[[Category: Stamm S]]

Latest revision as of 06:50, 1 May 2024

NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA

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