3go5: Difference between revisions

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[[Image:3go5.png|left|200px]]


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==Crystal structure of a multidomain protein with nucleic acid binding domains (sp_0946) from streptococcus pneumoniae tigr4 at 1.40 A resolution==
The line below this paragraph, containing "STRUCTURE_3go5", creates the "Structure Box" on the page.
<StructureSection load='3go5' size='340' side='right'caption='[[3go5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3go5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GO5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3go5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3go5 OCA], [https://pdbe.org/3go5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3go5 RCSB], [https://www.ebi.ac.uk/pdbsum/3go5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3go5 ProSAT], [https://www.topsan.org/Proteins/JCSG/3go5 TOPSAN]</span></td></tr>
{{STRUCTURE_3go5|  PDB=3go5  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H2UPM3_STRPN A0A0H2UPM3_STRPN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/3go5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3go5 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
CvfB is a conserved regulatory protein important for the virulence of Staphylococcus aureus. We show here that CvfB binds RNA. The crystal structure of the CvfB ortholog from Streptococcus pneumoniae at 1.4 A resolution reveals a unique RNA binding protein that is formed from a concatenation of well-known structural modules that bind nucleic acids: three consecutive S1 RNA binding domains and a winged helix (WH) domain. The third S1 and the WH domains are required for cooperative RNA binding and form a continuous surface that likely contributes to the RNA interaction. The WH domain is critical to CvfB function and contains a unique sequence motif. Thus CvfB represents a novel assembly of modules for binding RNA.


===Crystal structure of a multidomain protein with nucleic acid binding domains (sp_0946) from streptococcus pneumoniae tigr4 at 1.40 A resolution===
Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module.,Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA Structure. 2010 Mar 14;18(4):537-47. PMID:20399190<ref>PMID:20399190</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_20399190}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3go5" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20399190 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20399190}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3go5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GO5 OCA].
[[Category: Streptococcus pneumoniae TIGR4]]
 
==Reference==
<ref group="xtra">PMID:20399190</ref><references group="xtra"/>
[[Category: Streptococcus pneumoniae]]
[[Category: JCSG, Joint Center for Structural Genomics.]]

Latest revision as of 11:39, 1 February 2023

Crystal structure of a multidomain protein with nucleic acid binding domains (sp_0946) from streptococcus pneumoniae tigr4 at 1.40 A resolution

3go5, resolution 1.40Å

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