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New page: left|200px<br /><applet load="2onv" size="350" color="white" frame="true" align="right" spinBox="true" caption="2onv, resolution 1.610Å" /> '''Crystal Structure o...
 
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[[Image:2onv.gif|left|200px]]<br /><applet load="2onv" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2onv, resolution 1.610&Aring;" />
'''Crystal Structure of the amyloid-fibril forming peptide GGVVIA derived from the Alzheimer's amyloid Abeta (Abeta37-42).'''<br />


==Overview==
==Crystal Structure of the amyloid-fibril forming peptide GGVVIA derived from the Alzheimer's amyloid Abeta (Abeta37-42).==
Amyloid fibrils formed from different proteins, each associated with a, particular disease, contain a common cross-beta spine. The atomic, architecture of a spine, from the fibril-forming segment GNNQQNY of the, yeast prion protein Sup35, was recently revealed by X-ray, microcrystallography. It is a pair of beta-sheets, with the facing side, chains of the two sheets interdigitated in a dry 'steric zipper'. Here we, report some 30 other segments from fibril-forming proteins that form, amyloid-like fibrils, microcrystals, or usually both. These include, segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion, protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common, structural features are shared by amyloid diseases at the molecular level., Structures of 13 of these microcrystals all reveal steric zippers, but, with variations that expand the range of atomic architectures for, amyloid-like fibrils and offer an atomic-level hypothesis for the basis of, prion strains.
<StructureSection load='2onv' size='340' side='right'caption='[[2onv]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2onv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONV FirstGlance]. <br>
2ONV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONV OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2onv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onv OCA], [https://pdbe.org/2onv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2onv RCSB], [https://www.ebi.ac.uk/pdbsum/2onv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2onv ProSAT]</span></td></tr>
==Reference==
</table>
Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17468747 17468747]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Eisenberg, D.]]
[[Category: Large Structures]]
[[Category: Sambashivan, S.]]
[[Category: Eisenberg D]]
[[Category: Sawaya, M.R.]]
[[Category: Sambashivan S]]
[[Category: beta sheets]]
[[Category: Sawaya MR]]
[[Category: steric zipper]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:58:56 2008''

Latest revision as of 06:29, 3 April 2024

Crystal Structure of the amyloid-fibril forming peptide GGVVIA derived from the Alzheimer's amyloid Abeta (Abeta37-42).

2onv, resolution 1.61Å

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