Translocation domain: Difference between revisions
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==Group B colicins== | ==Group B colicins== | ||
All except for [[Colicin 5]] and [[Colicin 10]] use a single outer membrane protein for both binding and transport of the T domain into the periplasm, such as the | All except for [[Colicin 5]] and [[Colicin 10]] use a single outer membrane protein for both binding and transport of the T domain into the periplasm, such as the Cir protein. A proposed translocation mechanism of the colicin is<ref> PMID: 17347522 </ref>: | ||
Colicin binding to the outer membrane protein promotes an interaction between the outer membrane protein, and [[TonB]] in the periplasm. Energy from the PMF may open a pore in the outer membrane protein by removal of the plug domain of the protein, and allowing the T domain of the colicin to enter into the periplasm. Once inside, the T domain and TonB interact to allow entry of the cytotoxic domain. | Colicin binding to the outer membrane protein promotes an interaction between the outer membrane protein, and [[TonB]] in the periplasm. Energy from the PMF may open a pore in the outer membrane protein by removal of the plug domain of the protein, and allowing the T domain of the colicin to enter into the periplasm. Once inside, the T domain and TonB interact to allow entry of the cytotoxic domain. | ||
