3plz: Difference between revisions

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[[Image:3plz.jpg|left|200px]]


<!--
==Human LRH1 LBD bound to GR470==
The line below this paragraph, containing "STRUCTURE_3plz", creates the "Structure Box" on the page.
<StructureSection load='3plz' size='340' side='right'caption='[[3plz]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3plz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=470:(3AS,6AR)-5-[(4E)-OCT-4-EN-4-YL]-N,4-DIPHENYL-2,3,6,6A-TETRAHYDROPENTALEN-3A(1H)-AMINE'>470</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
{{STRUCTURE_3plz|  PDB=3plz  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3plz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plz OCA], [https://pdbe.org/3plz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3plz RCSB], [https://www.ebi.ac.uk/pdbsum/3plz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3plz ProSAT]</span></td></tr>
 
</table>
===Human LRH1 LBD bound to GR470===
== Function ==
 
[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_21391689}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 21391689 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_21391689}}
 
==About this Structure==
[[3plz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLZ OCA].  
 
==Reference==
<ref group="xtra">PMID:21391689</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Williams, S P.]]
[[Category: Large Structures]]
[[Category: Xu, R.]]
[[Category: Williams SP]]
[[Category: Zuercher, W J.]]
[[Category: Xu R]]
[[Category: Zuercher WJ]]

Latest revision as of 10:41, 21 February 2024

Human LRH1 LBD bound to GR470

3plz, resolution 1.75Å

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