2kxs: Difference between revisions

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[[Image:2kxs.jpg|left|200px]]


<!--
==ZO1 ZU5 domain in complex with GRINL1A peptide==
The line below this paragraph, containing "STRUCTURE_2kxs", creates the "Structure Box" on the page.
<StructureSection load='2kxs' size='340' side='right'caption='[[2kxs]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>
{{STRUCTURE_2kxs|  PDB=2kxs  |  SCENE=  }}
</table>
 
== Function ==
===ZO1 ZU5 domain in complex with GRINL1A peptide===
[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [https://www.uniprot.org/uniprot/MYZAP_HUMAN MYZAP_HUMAN] Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
 
== References ==
 
<references/>
<!--
__TOC__
The line below this paragraph, {{ABSTRACT_PUBMED_21240187}}, adds the Publication Abstract to the page
</StructureSection>
(as it appears on PubMed at http://www.pubmed.gov), where 21240187 is the PubMed ID number.
[[Category: Homo sapiens]]
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_21240187}}
[[Category: Synthetic construct]]
 
[[Category: Wen W]]
==About this Structure==
[[Category: Zhang M]]
[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_synthetic,_homo_sapiens Homo sapiens, synthetic, homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA].  
 
==Reference==
<ref group="xtra">PMID:21240187</ref><references group="xtra"/>
[[Category: Homo sapiens, synthetic, homo sapiens]]
[[Category: Wen, W.]]
[[Category: Zhang, M.]]

Latest revision as of 08:07, 10 April 2024

ZO1 ZU5 domain in complex with GRINL1A peptide

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