Phage integrase: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of Enterobacteria phage λ integrase [[1z1g]] {{STRUCTURE_1z1g| PDB=1z1g | SIZE=300| S |right|CAPTION= Enterobacteria phage λ integ...
 
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[[Image:1z1g.png|left|200px|thumb|Crystal Structure of Enterobacteria phage λ integrase [[1z1g]]]]
<StructureSection load='' size='400' side='right' scene='44/443479/Cv/2' caption='Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) [[1z1g]]' pspeed='8'>
{{STRUCTURE_1z1g|  PDB=1z1g  | SIZE=300| S |right|CAPTION= Enterobacteria phage λ integrase:DNA complex (Holiday Junction)
[1z1g]] }}


{{TOC limit|limit=2}}
'''Phage integrase''' (PIN) mediates recombination between DNA recognition sequences - the phage attachment site attP and the bacterial attachment site attB<ref>PMID:14687564</ref>.  The '''Tyrosine family PIN''' uses a catalytic tyrosine to mediate strand cleavage while the '''Serine family PIN''' uses a serine residue.  The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.
*The biological assembly of Enterobacteria phage λ integrase is <scene name='44/443479/Cv/3'>homotetramer</scene>.
</StructureSection>
== 3D Structures of phage integrase see [[Retroviral Integrase]]==


'''Phage integrase''' (PIN) mediate recombination between DNA recognition sequences - the phage attP and the bacterial attB.  The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue.  The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.


== 3D Structures of phage integrase ==
== References ==
 
<references/>
[[3nrw]] – PIN/site-specific recombinase N-terminal – ''Haloarcula marismortui''<br />
[[Category:Topic Page]]
[[3jtz]] – PIN arm-type binding domain – ''Yersinia pestis''<br />
[[3ju0]] – HPI PIN arm-type binding domain – ''Pectobacterium atrosepticum''<br />
[[2kkp]] – PIN SAM-like domain – ''Moorella thermoacetica'' – NMR<br />
[[2kkv]] – PIN fragment – ''Salmonella enterica'' – NMR<br />
[[2khq]] - PIN fragment – ''Staphylococcus saprophyticus'' – NMR<br />
[[2wcc]] – λPIN DBD+ DNA – Enterobacteria phage λ - NMR<br />
[[1kjk]] – λPIN N-terminal - NMR<br />
[[2oxo]], [[1z19]], [[1z1b]] - λPIN core binding domain + DNA<br />
[[1ae9]] - λPIN catalytic core domain (mutant) <br />
[[1z1g]] – λPIN + DNA (Holliday junction)<br />
[[1p7d]] – λPIN fragment + DNA <br />
[[3bvp]] – PIN catalytic core domain – Lactococcus phage TP101-1<br />
[[1aih]] - PIN catalytic core domain – Haemophilus phage HP1

Latest revision as of 06:20, 5 September 2018

Se-Met Enterobacteria phageλ integrase:DNA tetramer complex (Holiday Junction) 1z1g

Drag the structure with the mouse to rotate

3D Structures of phage integrase see Retroviral Integrase

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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