Sandbox Reserved 309: Difference between revisions
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=Function= | =Function= | ||
*Involved in nucleotide biosynthesis, which is very important as the intervention point for therapeutic agents. | *Involved in nucleotide biosynthesis, which is very important as the intervention point for therapeutic agents. | ||
*Catalyzes the reversible Mg2+ dependent transfer of the terminal phosphate group from ATP to AMP releasing two molecules of ADP. | *Catalyzes the reversible Mg2+ dependent transfer of the terminal phosphate group from ATP to AMP releasing two molecules of ADP or vice versa. | ||
*During the reaction, a molecule of ADP binds to the ATP-binding site, while the NMP-binding site binds either ADP or AMP. The ADP molecule is then phosphorylated in the ATP site and AMP is formed in the NMP site. <ref name=Bellinzoni>PMID: 16672241 </ref> | *During the reaction, a molecule of ADP binds to the ATP-binding site, while the NMP-binding site binds either ADP or AMP. The ADP molecule is then phosphorylated in the ATP site and AMP is formed in the NMP site. <ref name=Bellinzoni>PMID: 16672241 </ref> | ||
*LID and NMP binding regions go through a significant conformational change during the catalysis reaction | *LID and NMP binding regions go through a significant conformational change during the catalysis reaction. <ref name=Bellinzoni>PMID: 16672241 </ref> | ||
=Catalytic Mechanism= | =Catalytic Mechanism= | ||
The catalytic mechanism facilitated by adenylate kinase is depicted below: | The catalytic mechanism facilitated by adenylate kinase is depicted below: | ||
