Virus protease: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of HIV-1 protease [[1odw]] {{STRUCTURE_1odw| PDB=1odw | SIZE=300| S |right|CAPTION=HIV-1 protease 1odw }} '''Virus proteases''...
 
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<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
__TOC__
== Function ==
   
'''Virus protease''' or '''3C protease''' or '''virus proteinase''' are virus cysteine proteases which have essential role in viral replication.  The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref>  F


[[Image:1odw.png|left|200px|thumb|Crystal Structure of HIV-1 protease [[1odw]]]]
== Disease ==
{{STRUCTURE_1odw|  PDB=1odw  | SIZE=300| S |right|CAPTION=HIV-1 protease [[1odw]] }}


'''Virus proteases''' include HIV protease, XMRV protease, retropepsin.
Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.  Coxsakievirus causes the human diseases myocarditis and pericarditis.
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus.  Both are aspartyl proteases.  The inhibition of HIV-PR results in an uninfectious HIV virion.  HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.


== Structural highlights ==


{{TOC limit|limit=2}}
Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.


See also<br />


*[[Immunodeficiency virus protease]]<br />
*[[Human Immunodeficiency Virus]]<br />
*[[HIV-1 protease]]<br />
*[[HIV Protease Inhibitor Pharmacokinetics]]<br />
*[[HIV Protease Inhibitor Resistance Profile]]<br />
*[[HIV Protease Resistance]] <br />
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[FMDV 3C]] for Foot-and-Mouth virus protease<br />
*[[SARS Coronavirus Main Proteinase]]<br />
*[[SARS-CoV-2 Coronavirus Main Protease]]<br />
*[[Taylor SARS-CoV2 Protease]]<br />
== 3D Structures of Virus protease ==
[[Virus protease 3D structures]]
</StructureSection>


 
==References==
 
<references />
== 3D Structures of Virus proteases ==
[[Category:Topic Page]]
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