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New page: '''Unreleased structure''' The entry 3raw is ON HOLD Authors: Filippakopoulos, P., Fedorov, O., King, O., Bullock, A., Muniz, J.R.C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wei...
 
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'''Unreleased structure'''


The entry 3raw is ON HOLD
==Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41==
<StructureSection load='3raw' size='340' side='right'caption='[[3raw]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3raw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RA:5-(1,3-BENZODIOXOL-5-YLMETHYL)-2-(PHENYLAMINO)-4H-IMIDAZOL-4-ONE'>3RA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3raw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raw OCA], [https://pdbe.org/3raw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3raw RCSB], [https://www.ebi.ac.uk/pdbsum/3raw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3raw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref>


Authors: Filippakopoulos, P., Fedorov, O., King, O., Bullock, A., Muniz, J.R.C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
Description: Crystal Structure of human CDC-like kinase 3 isoform with a benzo-dioxol ligand
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bazureau JP]]
[[Category: Bountra C]]
[[Category: Bullock A]]
[[Category: Carreaux F]]
[[Category: Debdab M]]
[[Category: Edwards AM]]
[[Category: Fedorov O]]
[[Category: Filippakopoulos P]]
[[Category: King O]]
[[Category: Knapp S]]
[[Category: Meijer L]]
[[Category: Muniz JRC]]
[[Category: Renault S]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]
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