3qo2: Difference between revisions

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[[Image:3qo2.jpg|left|200px]]


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==Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9==
The line below this paragraph, containing "STRUCTURE_3qo2", creates the "Structure Box" on the page.
<StructureSection load='3qo2' size='340' side='right'caption='[[3qo2]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qo2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
{{STRUCTURE_3qo2|  PDB=3qo2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo2 OCA], [https://pdbe.org/3qo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo2 ProSAT]</span></td></tr>
 
</table>
===Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9===
== Function ==
 
[https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref>  
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_21419134}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 21419134 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_21419134}}
 
==About this Structure==
[[3qo2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO2 OCA].  
 
==Reference==
<ref group="xtra">PMID:21419134</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bedford, M T.]]
[[Category: Large Structures]]
[[Category: Chang, Y.]]
[[Category: Synthetic construct]]
[[Category: Cheng, X.]]
[[Category: Bedford MT]]
[[Category: Horton, J R.]]
[[Category: Chang Y]]
[[Category: Zhang, X.]]
[[Category: Cheng X]]
[[Category: Horton JR]]
[[Category: Zhang X]]

Latest revision as of 11:52, 14 March 2024

Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9

3qo2, resolution 2.49Å

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