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[[Image:1h0r.gif|left|200px]]<br />
<applet load="1h0r" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1h0r, resolution 2.10&Aring;" />
'''TYPE II DEHYDROQUINASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH 2,3-ANHYDRO-QUINIC ACID'''<br />


==About this Structure==
==Type II Dehydroquinase from Mycobacterium tuberculosis complexed with 2,3-anhydro-quinic acid==
1H0R is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with PO4, CL, FA1 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10]]. Structure known Active Site: FA1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H0R OCA]].  
<StructureSection load='1h0r' size='340' side='right'caption='[[1h0r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
[[Category: 3-dehydroquinate dehydratase]]
== Structural highlights ==
[[Category: Mycobacterium tuberculosis]]
<table><tr><td colspan='2'>[[1h0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. The April 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Concanavalin A and Circular Permutation''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_4 10.2210/rcsb_pdb/mom_2010_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0R FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Abell, C.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FA1:2,3+-ANHYDRO-QUINIC+ACID'>FA1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: Coggins, J.R.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0r OCA], [https://pdbe.org/1h0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0r RCSB], [https://www.ebi.ac.uk/pdbsum/1h0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0r ProSAT]</span></td></tr>
[[Category: Frederickson, M.]]
</table>
[[Category: Lapthorn, A.J.]]
== Function ==
[[Category: Robinson, D.A.]]
[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
[[Category: Roszak, A.W.]]
== Evolutionary Conservation ==
[[Category: CL]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: FA1]]
Check<jmol>
[[Category: GOL]]
  <jmolCheckbox>
[[Category: PO4]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0r_consurf.spt"</scriptWhenChecked>
[[Category: aromatic amino acid biosynthesis]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: dehydratase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: lyase]]
  </jmolCheckbox>
[[Category: shikimate pathway]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0r ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:53:42 2007''
==See Also==
*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Concanavalin A and Circular Permutation]]
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Abell C]]
[[Category: Coggins JR]]
[[Category: Frederickson M]]
[[Category: Lapthorn AJ]]
[[Category: Robinson DA]]
[[Category: Roszak AW]]

Latest revision as of 12:12, 13 December 2023

Type II Dehydroquinase from Mycobacterium tuberculosis complexed with 2,3-anhydro-quinic acid

1h0r, resolution 2.10Å

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