2l4m: Difference between revisions

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~~[[Image:2l4m.jpg|left|200px]]~~

~~<!--~~

==Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA==

~~The line below this paragraph, containing "STRUCTURE_2l4m", creates the "Structure Box" on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

== Structural highlights ==

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

<table><tr><td colspan='2'>[[2l4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4M FirstGlance]. <br>

~~or leave the SCENE parameter empty for the default display.~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

~~-->~~

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4m OCA], [https://pdbe.org/2l4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4m RCSB], [https://www.ebi.ac.uk/pdbsum/2l4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4m ProSAT]</span></td></tr>

~~{{STRUCTURE_2l4m| PDB=2l4m | SCENE= }}~~

</table>

== Function ==

===Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA===

[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).

__TOC__

</StructureSection>

==~~About this Structure~~==

[[2l4m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4M OCA].

[[Category: Homo sapiens]]

[[Category: Jeon~~, Y H.~~]]

[[Category: Large Structures]]

[[Category: Khayrutdinov~~, B I.~~]]

[[Category: Jeon YH]]

[[Category: Kim, K.]]

[[Category: Khayrutdinov BI]]

[[Category: Kim~~, K K.~~]]

[[Category: Kim K]]

[[Category: Kim KK]]

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@@ Line 1: / Line 1: @@
-[[Image:2l4m.jpg|left|200px]]
-<!--
+==Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA==
-The line below this paragraph, containing "STRUCTURE_2l4m", creates the "Structure Box" on the page.
+<StructureSection load='2l4m' size='340' side='right'caption='[[2l4m]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2l4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4M FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4m OCA], [https://pdbe.org/2l4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4m RCSB], [https://www.ebi.ac.uk/pdbsum/2l4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4m ProSAT]</span></td></tr>
-{{STRUCTURE_2l4m|  PDB=2l4m  |  SCENE=  }}
+</table>
+== Function ==
-===Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA===
+[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
+__TOC__
+</StructureSection>
-==About this Structure==
-[[2l4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4M OCA].
 [[Category: Homo sapiens]]
-[[Category: Jeon, Y H.]]
+[[Category: Large Structures]]
-[[Category: Khayrutdinov, B I.]]
+[[Category: Jeon YH]]
-[[Category: Kim, K.]]
+[[Category: Khayrutdinov BI]]
-[[Category: Kim, K K.]]
+[[Category: Kim K]]
+[[Category: Kim KK]]