Structural genomics: Difference between revisions

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Structural genomics is a large, international project, started around 2001, that aims to determine new protein structures using high throughput techniques, and to develop faster techniques for [[X-ray crystallography]] and [[NMR]].

Protein sequences are often selected for structure determination because they represent a sequence-family for which no member's structure is known. These are called ''target sequences''. Determination of the structure of such a sequence enables the structures of other sequence-related proteins to be predicted by [[homology modeling]]. Many of the institutions participating in structural genomics report their target sequences, and their progress in determining their structures, in [http://sbkb.org/tt/ TargetTrack, the Structural Biology Target Registration Database].

==Fold Space==

Andreeva and Murzin<ref name="andreeva">PMID: 20944210</ref> state:

Initially, it was anticipated that a large number of new folds would be discovered owing to the breath of coverage of fold space targeted by the PSI. Interestingly, this has not turned out to be the case as a substantial portion of the structures coming from SG revealed significant structural similarities to already known folds and in fact represent variations of existing protein architectures and topologies. <ref name="andreeva" />

</blockquote>

==See Also==

*[[Structural Genomics Consortium]]

* [http://www.nigms.nih.gov/Research/FeaturedPrograms/PSI/ Protein Structure Initiative (PSI)]

* [http://en.wikipedia.org/wiki/Structural_genomics Structural Genomics] at Wikipedia.

* The impact of extremophiles on structural genomics (and vice versa)<ref>PMID: 17563834</ref>.

Structural genomics: Difference between revisions

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 {{Stub}}
+Structural genomics is a large, international project, started around 2001, that aims to determine new protein structures using high throughput techniques, and to develop faster techniques for [[X-ray crystallography]] and [[NMR]].
+Protein sequences are often selected for structure determination because they represent a sequence-family for which no member's structure is known. These are called ''target sequences''. Determination of the structure of such a sequence enables the structures of other sequence-related proteins to be predicted by [[homology modeling]]. Many of the institutions participating in structural genomics report their target sequences, and their progress in determining their structures, in [http://sbkb.org/tt/ TargetTrack, the Structural Biology Target Registration Database].
+==Fold Space==
+Andreeva and Murzin<ref name="andreeva">PMID: 20944210</ref> state:
+<blockquote>
+Initially, it was anticipated that a large number of new folds would be discovered owing to the breath of coverage of fold space targeted by the PSI. Interestingly, this has not turned out to be the case as a substantial portion of the structures coming from SG revealed significant structural similarities to already known folds and in fact represent variations of existing protein architectures and topologies. <ref name="andreeva" />
+</blockquote>
 ==See Also==
 *[[Structural Genomics Consortium]]
+* [http://www.nigms.nih.gov/Research/FeaturedPrograms/PSI/ Protein Structure Initiative (PSI)]
 * [http://en.wikipedia.org/wiki/Structural_genomics Structural Genomics] at Wikipedia.
 * The impact of extremophiles on structural genomics (and vice versa)<ref>PMID: 17563834</ref>.