2hch: Difference between revisions

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New page: left|200px<br /><applet load="2hch" size="350" color="white" frame="true" align="right" spinBox="true" caption="2hch, resolution 2.30Å" /> '''N-Domain Of Grp94 In...
 
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[[Image:2hch.jpg|left|200px]]<br /><applet load="2hch" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2hch, resolution 2.30&Aring;" />
'''N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-amino)ethyl Carboxyamido Adenosine'''<br />


==About this Structure==
==N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-amino)ethyl Carboxyamido Adenosine==
2HCH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] with <scene name='pdbligand=N5A:'>N5A</scene>, <scene name='pdbligand=PG4:'>PG4</scene> and <scene name='pdbligand=1PE:'>1PE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCH OCA].  
<StructureSection load='2hch' size='340' side='right'caption='[[2hch]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2hch]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HCH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=N5A:5-N-[(2-AMINO)ETHYL+CARBOXAMIDO]+ADENOSINE'>N5A</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hch OCA], [https://pdbe.org/2hch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hch RCSB], [https://www.ebi.ac.uk/pdbsum/2hch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hch ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/2hch_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hch ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
__TOC__
</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Gewirth, D.T.]]
[[Category: Gewirth DT]]
[[Category: Immormino, R.M.]]
[[Category: Immormino RM]]
[[Category: 1PE]]
[[Category: N5A]]
[[Category: PG4]]
[[Category: adenosine]]
[[Category: chaperone]]
[[Category: grp94]]
[[Category: hsp82]]
[[Category: hsp90]]
[[Category: htpg]]
[[Category: ligand]]
[[Category: neaca]]
[[Category: neca]]
[[Category: neoca]]
[[Category: npca]]
 
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Retrieved from "https://proteopedia.org/2hch"