Chaperonin: Difference between revisions

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<StructureSection load='' size='350' side='right' caption='E. coli GroEL (green)/GroES (magenta) complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry [[1pcq]])' scene='44/445432/Cv/1'>
[[Image:1pcq.png|left|200px|thumb|Crystal Structure of Chaperonin, [[1pcq]]]]
[[Image:1pcq.png|left|200px|thumb|Crystal Structure of Chaperonin, [[1pcq]]]]
{{STRUCTURE_1pcq| PDB=1pcq | SIZE=300| SCENE=Chaperonin/Groel_groes_comnplex/1 |right|CAPTION=GroEL/GroES complex, [[1pcq]] }}
'''Chaperonins''' (Cpn) are oligomeric proteins that mediate the folding of polypeptide chains. '''Group I CPN''' are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia].


Chaperonin (CPN) are oligomeric proteins which mediate the folding of polypeptide chains.  Group I CPNs are found in bacteria, chloroplasts and mitochondria.  They include the most characterized GroEL/GroES complex from ''Escherichia coli'' and CPN60/CPN10 from ''Thermus thermophilus''.  The larger subunit (GroEL, CPN60) contains 3 domains.  The apical domain is the one which binds the substrate.  Group II CPNs are found in eukaryotic cytosol and archaea.  Thermosome is a CPN complex found in archaea.  CCT is a CPN complex found in eukarya.
The most characterized Cpn are in the GroEL/GroES complex from ''Escherichia coli'' and Cpn60/Cpn10 from ''Thermus thermophilus''.<ref>PMID:18987317</ref> The larger subunit (GroEL, Cpn60) contains 3 domains: apical, intermediate and equatorial domain.  The apical domain is the one which binds the polypeptide substrate. The equatorial domains binds the nucleotide.   
 
*'''Group II Cpns''' are found during mitosis in eukaryotic cytosol and archaea.   
{{TOC limit|limit=2}}
*'''Thermosome''' is a Cpn complex found in archaea.<ref>PMID:9546398</ref>  
*'''CCT''' or '''TRiC''' is a Cpn complex found in eukarya believed to be involved in uncontrolled proliferation.<ref>PMID:22503819</ref>, <ref>PMID:32297209</ref>
*<scene name='44/445432/Cv/2'>E. coli GroEL/GroES complex</scene> (GroEL in green, GroES in magenta, PDB entry [[1pcq]]).
*<scene name='44/445432/Cv/3'>GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions</scene>.
*<scene name='44/445432/Cv/5'>K+ ion coordination site</scene>. GroEL in cyan.
*<scene name='44/445432/Cv/6'>AlF3 binding site</scene>.
*<scene name='44/445432/Cv/7'>Mg+2 ion coordination site</scene>.
*<scene name='44/445432/Cv/9'>ADP binding site</scene>.
*<scene name='44/445432/Cv/10'>Whole binding site</scene>.
*See also [[Chaperones]].<br />
*For GroEl in Hebrew see [[Sand box groel]].


== 3D Structures of Chaperonin ==
== 3D Structures of Chaperonin ==
[[Chaperonin 3D structures]]


== Files for 3D printer ==
<i class="fas fa-cubes"></i> Asymmetric Chaperonin Complex GroEL/GroES by [[User:Marius Mihasan|Marius Mihasan]] [https://3dprint.nih.gov/discover/3dpx-017057  <i class="fas fa-download"></i>]


</StructureSection>


 
== References ==
 
<references/>
 
[[Category:Topic Page]]
 
[[Category:3D printer files]]
 
[Category:Topic Page]]
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