Ton: Difference between revisions

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==Structure==

The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex,

The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex.

==Function==

The ~~ton~~ proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.

The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell<ref>PMID: 17347522</ref>, and the system as a whole is known to be an energy-transducing system. Each of the three proteins involved have their separate role<ref name='Held'>PMID: 12193634</ref>. For more information, see the respective pages for TonB, ExbB and ExbD.

~~==Interaction of~~ Ton ~~proteins~~==

The Ton system can be exploited by group B Colicins {see [[Colicin]] for more details) which include<ref name="Cascales">PMID: 17347522</ref><ref name='Davies'>PMID: 124727</ref>:

*[[Colicin 5]]

*[[Colicin 6]]

*[[Colicin 7]]

*[[Colicin 8]]

*[[Colicin 9]]

*[[Colicin 10]]

*[[Colicin Ia]]

*[[Colicin Ib]]

*[[Colicin B]]

*[[Colicin D]]

*[[Colicin M]]

*[[Colicin V]]

*[[Colicin Js]]

*[[Colicin Y]]

It is interesting to note that the name 'Ton' comes its resistance to the T1 phage<ref name='Davies'>PMID: 124727</ref>.

==Interaction ~~with Colicin~~==

==Interaction of Ton proteins==

~~The~~ Ton proteins ~~regularly~~ interact with ~~colicins~~.

Like in the [[Tol]] complex, the Ton system proteins interact with each other<ref>PMID: 9811664</ref>:

# the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane.

# ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction

==~~Regulation~~==

==3D structures of TonB==

[[TonB]]

== References==

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@@ Line 2: / Line 2: @@
 ==Structure==
-The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex,
+The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex.
 ==Function==
-The ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.
+The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell<ref>PMID: 17347522</ref>, and the system as a whole is known to be an energy-transducing system.  Each of the three proteins involved have their separate role<ref name='Held'>PMID: 12193634</ref>.  For more information, see the respective pages for TonB, ExbB and ExbD.
-==Interaction of Ton proteins==
+The Ton system can be exploited by group B Colicins {see [[Colicin]] for more details) which include<ref name="Cascales">PMID: 17347522</ref><ref name='Davies'>PMID: 124727</ref>:
+*[[Colicin 5]]
+*[[Colicin 6]]
+*[[Colicin 7]]
+*[[Colicin 8]]
+*[[Colicin 9]]
+*[[Colicin 10]]
+*[[Colicin Ia]]
+*[[Colicin Ib]]
+*[[Colicin B]]
+*[[Colicin D]]
+*[[Colicin M]]
+*[[Colicin V]]
+*[[Colicin Js]]
+*[[Colicin Y]]
+It is interesting to note that the name 'Ton' comes its resistance to the T1 phage<ref name='Davies'>PMID: 124727</ref>.
-==Interaction with Colicin==
+==Interaction of Ton proteins==
-The Ton proteins regularly interact with colicins.
+Like in the [[Tol]] complex, the Ton system proteins interact with each other<ref>PMID: 9811664</ref>:
+# the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane.
+# ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction
-==Regulation==
+==3D structures of TonB==
+[[TonB]]
 == References==
 <references/>