TolQ: Difference between revisions

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[[Image:TolQ.jpg|600px|right|thumb| The TolQ Membrane-spanning domains <ref>PMID: 8662905</ref>]]

==Structure==

TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids. There are three membrane spanning segments in TolQ with each segment containing an α-helix<ref>PMID: 7853390</ref>. TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm. This topology is also found in [[ExbB]], which can be explained by the similar sequence shared by both proteins<ref name='Braun'>PMID: 15205446</ref>.

'''TolQ''' is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids. There are three membrane spanning segments in TolQ with each segment containing an α-helix<ref>PMID: 7853390</ref>. TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm. This topology is also found in [[ExbB]], which can be explained by the similar sequence shared by both proteins<ref name='Braun'>PMID: 15205446</ref>.

It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA<ref> PMID: 21285349</ref>. The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction<ref name='Vianney'> PMID:8300535</ref>.

It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, [[TolR]] and [[TolA]]<ref> PMID: 21285349</ref>. The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction<ref name='Vianney'> PMID:8300535</ref>.

==Function==

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 [[Image:TolQ.jpg|600px|right|thumb| The TolQ Membrane-spanning domains <ref>PMID: 8662905</ref>]]
 ==Structure==
-TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids.  There are three membrane spanning segments in TolQ with each segment containing an α-helix<ref>PMID: 7853390</ref>.  TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm.  This topology is also found in [[ExbB]], which can be explained by the similar sequence shared by both proteins<ref name='Braun'>PMID: 15205446</ref>.
+'''TolQ''' is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids.  There are three membrane spanning segments in TolQ with each segment containing an α-helix<ref>PMID: 7853390</ref>.  TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm.  This topology is also found in [[ExbB]], which can be explained by the similar sequence shared by both proteins<ref name='Braun'>PMID: 15205446</ref>.
-It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA<ref> PMID: 21285349</ref>.  The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction<ref name='Vianney'> PMID:8300535</ref>.
+It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, [[TolR]] and [[TolA]]<ref> PMID: 21285349</ref>.  The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction<ref name='Vianney'> PMID:8300535</ref>.
 ==Function==