Ton: Difference between revisions
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The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell<ref>PMID: 17347522</ref>, and the system as a whole is known to be an energy-transducing system. Each of the three proteins involved have their separate role<ref name='Held'>PMID: 12193634</ref>. For more information, see the respective pages for TonB, ExbB and ExbD. | The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell<ref>PMID: 17347522</ref>, and the system as a whole is known to be an energy-transducing system. Each of the three proteins involved have their separate role<ref name='Held'>PMID: 12193634</ref>. For more information, see the respective pages for TonB, ExbB and ExbD. | ||
The Ton system can be exploited by group B Colicins {see [[Colicin]] for more details) which include: | The Ton system can be exploited by group B Colicins {see [[Colicin]] for more details) which include<ref name="Cascales">PMID: 17347522</ref><ref name='Davies'>PMID: 124727</ref>: | ||
*[[Colicin 5]] | *[[Colicin 5]] | ||
*[[Colicin 6]] | *[[Colicin 6]] | ||
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*[[Colicin Js]] | *[[Colicin Js]] | ||
*[[Colicin Y]] | *[[Colicin Y]] | ||
It is interesting to note that the name 'Ton' comes its resistance to the T1 phage<ref name='Davies'>PMID: 124727</ref>. | |||
==Interaction of Ton proteins== | ==Interaction of Ton proteins== | ||
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# the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane. | # the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane. | ||
# ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction | # ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction | ||
==3D structures of TonB== | |||
[[TonB]] | |||
== References== | == References== | ||
<references/> | <references/> | ||
