3rm1: Difference between revisions
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New page: '''Unreleased structure''' The entry 3rm1 is ON HOLD Authors: LIRIANO, M.A., WEBER,D.J Description: 1.24 ANGSTROM X-RAY STRUCTURE OF BOVINE TRTK12-CA(2+)-S100B D63N |
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==1.24 Angstrom X-ray structure of bovine TRTK12-Ca(2+)-S100B D63N== | |||
<StructureSection load='3rm1' size='340' side='right'caption='[[3rm1]], [[Resolution|resolution]] 1.24Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RM1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rm1 OCA], [https://pdbe.org/3rm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rm1 RCSB], [https://www.ebi.ac.uk/pdbsum/3rm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rm1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | |||
==See Also== | |||
*[[S100 proteins 3D structures|S100 proteins 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Liriano MA]] | |||
[[Category: Weber DJ]] | |||
Latest revision as of 12:29, 14 March 2024
1.24 Angstrom X-ray structure of bovine TRTK12-Ca(2+)-S100B D63N
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