3rmu: Difference between revisions
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New page: '''Unreleased structure''' The entry 3rmu is ON HOLD Authors: Chaikuad, A., Krysztofinska, E., Froese, D.S. , Yue, W.W., Vollmar, M., Muniz, J.R.C., von Delft, F., Weigelt, J. , Arrowsm... |
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==Crystal structure of human Methylmalonyl-CoA epimerase, MCEE== | |||
<StructureSection load='3rmu' size='340' side='right'caption='[[3rmu]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rmu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RMU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rmu OCA], [https://pdbe.org/3rmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rmu RCSB], [https://www.ebi.ac.uk/pdbsum/3rmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rmu ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN] Vitamin B12-unresponsive methylmalonic acidemia. Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:[https://omim.org/entry/251120 251120]: Autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16752391</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Chaikuad A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Froese DS]] | |||
[[Category: Krysztofinska E]] | |||
[[Category: Muniz JRC]] | |||
[[Category: Oppermann U]] | |||
[[Category: Vollmar M]] | |||
[[Category: Weigelt J]] | |||
[[Category: Yue WW]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 09:44, 1 March 2024
Crystal structure of human Methylmalonyl-CoA epimerase, MCEE
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