2rrb: Difference between revisions

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[[Image:2rrb.jpg|left|200px]]


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==Refinement of RNA binding domain in human Tra2 beta protein==
The line below this paragraph, containing "STRUCTURE_2rrb", creates the "Structure Box" on the page.
<StructureSection load='2rrb' size='340' side='right'caption='[[2rrb]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rrb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrb OCA], [https://pdbe.org/2rrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrb RCSB], [https://www.ebi.ac.uk/pdbsum/2rrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrb ProSAT]</span></td></tr>
{{STRUCTURE_2rrb|  PDB=2rrb  |  SCENE=  }}
</table>
 
== Function ==
===Refinement of RNA binding domain in human Tra2 beta protein===
[https://www.uniprot.org/uniprot/TRA2B_HUMAN TRA2B_HUMAN] Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.<ref>PMID:9546399</ref> <ref>PMID:12165565</ref> <ref>PMID:12761049</ref> <ref>PMID:15009664</ref>  
 
== References ==
 
<references/>
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</StructureSection>
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{{ABSTRACT_PUBMED_20926394}}
 
==About this Structure==
[[2rrb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRB OCA].  
 
==Reference==
<ref group="xtra">PMID:20926394</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inoue, M.]]
[[Category: Large Structures]]
[[Category: Kigawa, T.]]
[[Category: Inoue M]]
[[Category: Kuwasako, K.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Kuwasako K]]
[[Category: Shirouzu, M.]]
[[Category: Muto Y]]
[[Category: Someya, T.]]
[[Category: Shirouzu M]]
[[Category: Sugano, S.]]
[[Category: Someya T]]
[[Category: Takahashi, M.]]
[[Category: Sugano S]]
[[Category: Terada, T.]]
[[Category: Takahashi M]]
[[Category: Tsuda, K.]]
[[Category: Terada T]]
[[Category: Yokoyama, S.]]
[[Category: Tsuda K]]
[[Category: Yokoyama S]]