3r84: Difference between revisions
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< | ==Structure of the Mediator head subcomplex Med11/22== | ||
<StructureSection load='3r84' size='340' side='right'caption='[[3r84]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3r84]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R84 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r84 OCA], [https://pdbe.org/3r84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r84 RCSB], [https://www.ebi.ac.uk/pdbsum/3r84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r84 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mediator is a multiprotein co-activator of RNA polymerase (Pol) II transcription. Mediator contains a conserved core that comprises the 'head' and 'middle' modules. We present here a structure-function analysis of the essential Med11/22 heterodimer, a part of the head module. Med11/22 forms a conserved four-helix bundle domain with C-terminal extensions, which bind the central head subunit Med17. A highly conserved patch on the bundle surface is required for stable transcription pre-initiation complex formation on a Pol II promoter in vitro and in vivo and may recruit the general transcription factor TFIIH. The bundle domain fold is also present in the Mediator middle module subcomplex Med7/21 and is predicted in the Mediator heterodimers Med2/3, Med4/9, Med10/14 and Med28/30. The bundle domain thus represents a common building block that has been multiplied and functionally diversified during Mediator evolution in eukaryotes. | |||
Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.,Seizl M, Lariviere L, Pfaffeneder T, Wenzeck L, Cramer P Nucleic Acids Res. 2011 Apr 15. PMID:21498544<ref>PMID:21498544</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3r84" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Mediator|Mediator]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | [[Category: Large Structures]] | ||
[[ | |||
== | |||
< | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Cramer | [[Category: Cramer P]] | ||
[[Category: Lariviere | [[Category: Lariviere L]] | ||
[[Category: Pfaffenender | [[Category: Pfaffenender T]] | ||
[[Category: Seizl | [[Category: Seizl M]] | ||
[[Category: Wenzeck | [[Category: Wenzeck L]] | ||
Latest revision as of 02:20, 21 November 2024
Structure of the Mediator head subcomplex Med11/22
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