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New page: left|200px<br /><applet load="1zph" size="350" color="white" frame="true" align="right" spinBox="true" caption="1zph, resolution 1.80Å" /> '''Crystal structure an...
 
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[[Image:1zph.gif|left|200px]]<br /><applet load="1zph" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1zph, resolution 1.80&Aring;" />
'''Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8315 complexed with CGCGAATTCGCG'''<br />


==Overview==
==Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8315 complexed with CGCGAATTCGCG==
The structures of the complexes formed between two anticancer, minor-groove-binding quinolinium quaternary salts and the dodecamer, d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8, Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the, structures are isomorphous with previously solved dodecamer structures., The ligands both bind in the central AT region of the minor groove and, although the crystallization conditions and structures of the ligands are, very similar, they bind in opposing orientations. The structures are, compared with two previously published structures of quinolinium, quaternary salts, refined at 2.5 Angstrom resolution, complexed with, d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.
<StructureSection load='1zph' size='340' side='right'caption='[[1zph]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1zph]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZPH FirstGlance]. <br>
1ZPH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SN8:'>SN8</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPH OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SN8:1,6-DIMETHYL-4-(4-(4-(1-METHYLPYRIDINIUM-4-YLAMINO)PHENYLCARBAMOYL)PHENYLAMINO)QUINOLINIUM'>SN8</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zph OCA], [https://pdbe.org/1zph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zph RCSB], [https://www.ebi.ac.uk/pdbsum/1zph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zph ProSAT]</span></td></tr>
Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16204886 16204886]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Adams, A.]]
</StructureSection>
[[Category: Denny, W.A.]]
[[Category: Large Structures]]
[[Category: Guss, J.M.]]
[[Category: Adams A]]
[[Category: Leong, C.]]
[[Category: Denny WA]]
[[Category: MG]]
[[Category: Guss JM]]
[[Category: SN8]]
[[Category: Leong C]]
[[Category: b-dna]]
[[Category: dodecamer]]
[[Category: minor groove binding complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:40:10 2008''

Latest revision as of 09:06, 14 February 2024

Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8315 complexed with CGCGAATTCGCG

1zph, resolution 1.80Å

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