1a4j: Difference between revisions

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[[Image:1a4j.png|left|200px]]


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==DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR==
The line below this paragraph, containing "STRUCTURE_1a4j", creates the "Structure Box" on the page.
<StructureSection load='1a4j' size='340' side='right'caption='[[1a4j]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a4j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A4J FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4j OCA], [https://pdbe.org/1a4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a4j RCSB], [https://www.ebi.ac.uk/pdbsum/1a4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4j ProSAT]</span></td></tr>
{{STRUCTURE_1a4j|  PDB=1a4j  |  SCENE=  }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN] Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD) [MIM:[https://omim.org/entry/614102 614102]. IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.<ref>PMID:3931219</ref>
== Function ==
[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/1a4j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a4j ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure of an antibody (39-A11) that catalyzes a Diels-Alder reaction has been determined. The structure suggests that the antibody catalyzes this pericyclic reaction through a combination of packing and hydrogen-bonding interactions that control the relative geometries of the bound substrates and electronic distribution in the dienophile. A single somatic mutation, serine-91 of the light chain to valine, is largely responsible for the increase in affinity and catalytic activity of the affinity-matured antibody. Structural and functional studies of the germ-line precursor suggest that 39-A11 and related antibodies derive from a family of germ-line genes that have been selected throughout evolution for the ability of the encoded proteins to form a polyspecific combining site. Germ line-encoded antibodies of this type, which can rapidly evolve into high-affinity receptors for a broad range of structures, may help to expand the binding potential associated with the structural diversity of the primary antibody repertoire.


===DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR===
Immunological origins of binding and catalysis in a Diels-Alderase antibody.,Romesberg FE, Spiller B, Schultz PG, Stevens RC Science. 1998 Mar 20;279(5358):1929-33. PMID:9506942<ref>PMID:9506942</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1a4j" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_9506942}}, adds the Publication Abstract to the page
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9506942 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_9506942}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[1a4j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4J OCA].
 
==Reference==
<ref group="xtra">PMID:009506942</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Romesburg, F E.]]
[[Category: Romesburg FE]]
[[Category: Schultz, P G.]]
[[Category: Schultz PG]]
[[Category: Spiller, B W.]]
[[Category: Spiller BW]]
[[Category: Stevens, R C.]]
[[Category: Stevens RC]]
[[Category: Antibody]]
[[Category: Catalytic antibody]]
[[Category: Diels alder]]
[[Category: Germline]]
[[Category: Immunoglobulin]]
Retrieved from "https://proteopedia.org/1a4j"