1a3y: Difference between revisions

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[[Image:1a3y.png|left|200px]]


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==ODORANT BINDING PROTEIN FROM NASAL MUCOSA OF PIG==
The line below this paragraph, containing "STRUCTURE_1a3y", creates the "Structure Box" on the page.
<StructureSection load='1a3y' size='340' side='right'caption='[[1a3y]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3Y FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3y OCA], [https://pdbe.org/1a3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3y RCSB], [https://www.ebi.ac.uk/pdbsum/1a3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3y ProSAT]</span></td></tr>
{{STRUCTURE_1a3y|  PDB=1a3y  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/OBP_PIG OBP_PIG] This protein is found in nasal epithelium and it binds a wide variety of chemical odorants.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3y ConSurf].
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The X-ray structure of the porcine odorant binding protein (OBPp) was determined at 2.25 A resolution. This lipocalin is a monomer and is devoid of naturally occurring bound ligand, contrary to what was observed in the case of bovine OBP [Tegoni, M., et al. (1996) Nat. Struct. Biol. 3, 863-867; Bianchet, M. A., et al. (1996) Nat. Struct. Biol. 3, 934-939]. In this latter protein, a dimer without any disulfide bridges, domain swapping was found to occur between the beta- and alpha-domains. A single Gly (121) insertion was found in OBPp when it was compared to OBPb, which may prevent domain swapping from taking place. The presence of a disulfide bridge between the OBPp beta- and alpha-domains (cysteines 63 and 155) may lock the resulting fold in a nonswapped monomeric conformation. Comparisons with other OBPs indicate that the two cysteines involved in the OBPp disulfide bridge are conserved in the sequence, suggesting that OBPp may be considered a prototypic OBP fold, and not OBPb.


===ODORANT BINDING PROTEIN FROM NASAL MUCOSA OF PIG===
The structure of the monomeric porcine odorant binding protein sheds light on the domain swapping mechanism.,Spinelli S, Ramoni R, Grolli S, Bonicel J, Cambillau C, Tegoni M Biochemistry. 1998 Jun 2;37(22):7913-8. PMID:9609684<ref>PMID:9609684</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1a3y" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_9609684}}, adds the Publication Abstract to the page
*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9609684 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_9609684}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[1a3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3Y OCA].
 
==Reference==
<ref group="xtra">PMID:009609684</ref><references group="xtra"/>
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Cambillau, C.]]
[[Category: Cambillau C]]
[[Category: Spinelli, S.]]
[[Category: Spinelli S]]
[[Category: Tegoni, M.]]
[[Category: Tegoni M]]
[[Category: Lipocalin]]
[[Category: Olfaction]]
Retrieved from "https://proteopedia.org/1a3y"