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New page: left|200px<br /><applet load="1zvn" size="350" color="white" frame="true" align="right" spinBox="true" caption="1zvn, resolution 2.16Å" /> '''Crystal structure of...
 
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[[Image:1zvn.gif|left|200px]]<br /><applet load="1zvn" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1zvn, resolution 2.16&Aring;" />
'''Crystal structure of chick MN-cadherin EC1'''<br />


==Overview==
==Crystal structure of chick MN-cadherin EC1==
Type I and II classical cadherins help to determine the adhesive, specificities of animal cells. Crystal-structure determination of, ectodomain regions from three type II cadherins reveals adhesive dimers, formed by exchange of N-terminal beta strands between partner, extracellular cadherin-1 (EC1) domains. These interfaces have two, conserved tryptophan side chains that anchor each swapped strand, compared, with one in type I cadherins, and include large hydrophobic regions unique, to type II interfaces. The EC1 domains of type I and type II cadherins, appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends, on EC1 domain identity, suggesting that this region, which includes the, structurally defined adhesive interface, encodes type II cadherin, functional specificity in vivo.
<StructureSection load='1zvn' size='340' side='right'caption='[[1zvn]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1zvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZVN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvn OCA], [https://pdbe.org/1zvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvn RCSB], [https://www.ebi.ac.uk/pdbsum/1zvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAD20_CHICK CAD20_CHICK] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.<ref>PMID:12007407</ref> <ref>PMID:15992777</ref> <ref>PMID:16564015</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zvn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zvn ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1ZVN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVN OCA].
*[[Cadherin 3D structures|Cadherin 3D structures]]
 
== References ==
==Reference==
<references/>
Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16564015 16564015]
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bahna, F.]]
[[Category: Bahna F]]
[[Category: Chen, C.P.]]
[[Category: Chen CP]]
[[Category: Ciatto, C.]]
[[Category: Ciatto C]]
[[Category: Honig, B.]]
[[Category: Honig B]]
[[Category: Jessell, T.M.]]
[[Category: Jessell TM]]
[[Category: Patel, S.D.]]
[[Category: Patel SD]]
[[Category: Price, S.R.]]
[[Category: Price SR]]
[[Category: Rajebhosale, M.]]
[[Category: Rajebhosale M]]
[[Category: Schieren, I.]]
[[Category: Schieren I]]
[[Category: Shapiro, L.]]
[[Category: Shapiro L]]
[[Category: cadherin]]
[[Category: strand dimer]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:43:51 2008''

Latest revision as of 09:07, 14 February 2024

Crystal structure of chick MN-cadherin EC1

1zvn, resolution 2.16Å

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