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New page: left|200px<br /><applet load="1zw0" size="350" color="white" frame="true" align="right" spinBox="true" caption="1zw0, resolution 1.80Å" /> '''Crystal structure of...
 
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[[Image:1zw0.gif|left|200px]]<br /><applet load="1zw0" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1zw0, resolution 1.80&Aring;" />
'''Crystal structure of the Yersinia Type III Secretion protein YscE'''<br />


==Overview==
==Crystal structure of the Yersinia Type III Secretion protein YscE==
The plague-causing bacterium Yersinia pestis utilizes a contact-dependent, (type III) secretion system (T3SS) to transport virulence factors from the, bacterial cytosol directly into the interior of mammalian cells where they, interfere with signal transduction pathways that mediate phagocytosis and, the inflammatory response. The type III secretion apparatus is composed of, 20-25 different Yersinia secretion (Ysc) proteins. We report here the, structure of YscE, the smallest Ysc protein, which is a dimer in solution., The probable mode of oligomerization is discussed.
<StructureSection load='1zw0' size='340' side='right'caption='[[1zw0]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1zw0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZW0 FirstGlance]. <br>
1ZW0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW0 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw0 OCA], [https://pdbe.org/1zw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zw0 RCSB], [https://www.ebi.ac.uk/pdbsum/1zw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw0 ProSAT]</span></td></tr>
==Reference==
</table>
Crystal structure of the Yersinia type III secretion protein YscE., Phan J, Austin BP, Waugh DS, Protein Sci. 2005 Oct;14(10):2759-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16195558 16195558]
== Function ==
[[Category: Single protein]]
[https://www.uniprot.org/uniprot/O68692_YERPE O68692_YERPE]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
[[Category: Austin, B.P.]]
[[Category: Austin BP]]
[[Category: Phan, J.]]
[[Category: Phan J]]
[[Category: Waugh, D.S.]]
[[Category: Waugh DS]]
[[Category: chaperone]]
[[Category: export]]
[[Category: translocation]]
[[Category: type iii secretion]]
[[Category: yersinia]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:44:04 2008''
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